Looking for an academic partner for your discovery projects?
Looking for an academic partner for your discovery projects?
Ghent University offers a unique proposal: the collaboration between veterinarians, physicians and scientists from different disciplines present at Ghent University takes the research to a higher level and creates many opportunities for innovation. At our Faculty of Veterinary Medicine these innovations can be tested in our own facilities and on the target species.
Check what we can offer in these fields
Ghent University offers a unique proposal: the collaboration between veterinarians, physicians and scientists from different disciplines present at Ghent University takes the research to a higher level and creates many opportunities for innovation. At our Faculty of Veterinary Medicine these innovations can be tested in our own facilities and on the target species.
Check what we can offer in these fields
Delivery systems
Nanoparticle system for improved pulmonary delivery
An endogenous protein that strongly improves lung cell permeability for cytosolic delivery
SP-B is an endogenous protein that, as a key component in lung surfactant, strongly improves lung cell permeability for cytosolic delivery.
SP-B, combined with our nanoparticle technology, can be applied to deliver various cargo (such as proteins, drug molecules and siRNA) to pulmonary cells.
Proof of concept
SP-B’s functionality was integrated in a proteolipid nanoparticle by enveloping an siRNA loaded dextrane core with a specific composition of lipids and SP-B. The developed nanocomposites have a low in vivo toxicity and show a high uptake by alveolar macrophages.
Partnering
We seek partnerships to explore SP-B technology for delivery of macromolecules in disease of interest or for benchmarking/validation studies for local pulmonary applications.